![]() It has been proposed that PVC-induced cough happens due to the cardiopulmonary reflex ( 6). Symptoms were resolved immediately with the suppression of the PVCs, supporting the causal relationship. We report the case of a 44-year-old female who presented to our hospital for PVCs with chronic cough and cough syncope. Surprisingly, cough disappeared after radiofrequency ablation, and no recurrence of arrhythmia or cough was observed ( Figure 5). Therefore, radiofrequency ablation of the arrhythmogenic focus was proposed. Subsequent treatment with oral antiarrhythmic drugs was ineffective. Two-dimensional color echocardiography was normal except for trivial regurgitant flow ( Figure 4). The frequent occurrence of PVCs was associated with repetitive coughing. The 24 h-Holter ECG monitor showed normal sinus rhythm with 27553 PVCs ( Figure 3). The patient's electrocardiogram (ECG) showed normal sinus rhythm with frequent premature ventricular beats (PVCs) ( Figure 2). In pulmonary function testing, the forced vital capacity (FVC) was 2.99 L (100.9% of predicted value), the forced expiratory volume in 1 s (FEV 1) was 2.45 L (96.5% of predicted value), and the FEV 1/FVC ratio was 81.99% ( Figure 1C). The methacholine challenge test for bronchial hyperreactivity was negative ( Figure 1B). Chest high-resolution CT (HRCT) ( Figure 1A), pulmonary ventilation and single-breath diffusing capacity of the lung for carbon monoxide were normal. White blood cell count, eosinophil count, and serum immunoglobulin E (39.1 IU/mL, normal value <100 IU/mL) were normal. The patient presented no abnormality on physical examination. She had no known allergies and denied smoking. She denied chest pain, chest distress, shortness of breath, heartburn, or acid regurgitation. Seven months prior, the chest film and spirometry test were almost normal however, 4 months prior, the cough returned and the patient suffered from cough-related syncope for 3 h. She was diagnosed with chronic cough and was treated with cough medications for cough symptoms, which did not prevent the disease from worsening. The respiratory symptoms were predominantly nocturnal and more severe in the winter. This 44-year-old female presented with daily productive cough and expectoration for 4 years and experienced recurrence for more than half a year. This case report describes a patient with premature ventricular beats (PVCs) presenting with chronic cough and cough syncope. Various causes of chronic cough have been found, including upper airway cough syndrome, gastroesophageal reflux disease (GERD)/laryngopharyngeal reflux disease, asthma, and non-asthmatic eosinophilic bronchitis (NAEB) however, almost 7% of all chronic coughs are unexplained ( 3– 5). Chronic cough, which is defined as a cough lasting for more than 8 weeks, is the most common symptom that accompanies a diverse range of respiratory diseases, non-respiratory conditions, and rarer conditions ( 1, 2).
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